Showing posts with label for resistance to stress. Show all posts
Showing posts with label for resistance to stress. Show all posts

Friday, February 19, 2010

Why Stress Makes Us Fat?

This is the transcript from my recent podcast on the tendency of chronic stress (and cortisol overexposure and general metabolic imbalance) to lead to abdominal obesity (too much belly fat and the resulting diabetes). Take a listen to the podcast HERE - or read the transcript below.

Hi, this is Dr. Shawn Talbott – and I want to welcome you to another podcast fromwww.WisdomofBalance.com

Today, I’m going to talk about “Why stress makes us fat” and also about two of the most common New Years Resolutions that are made every year – the first being to “lose some weight” (or get fit or a similar fitness oriented goal) and the second being to “reduce stress” (or get organized or something else related to helping us feel better and be happier). What I want to focus on today is the idea that achieving a completely different goal might be the way for you to get it all – and finally lose weight and reduce stress and feel better all at the same time. The way you achieve all of this is by working to restore biochemical balance in your body – because it’s that biochemical balance that is upset by stress and it’s that upset balance that leads to weight gain, depression, fatigue, mental fog, and general burnout that we’re all trying to turn around. But, we simply can’t turn anything around until we first restore biochemical balance within our body – and that’s what I’ll talk about in this podcast.

Whenever I lecture about the detrimental health effects of stress, and especially its effects on weight gain, I start off my seminars by asking members of the audience three simple questions:

1.Got stress? Of course you do! That’s strike one.

2.How about sleep—do you get less than eight solid hours of restful sleep every night? Yes? Strike two.

3.What about your diet—are you among the millions of people who are actively dieting or concerned about what you eat? Yes? Strike three.

As you might imagine, most people have three strikes. In our fast-paced, hurry-hurry, twenty-first-century world, almost of all of us are stressed out, sleep deprived, and hyper-concerned about our diet and food choices. Because of this chronic stress, unfortunately, most of us are also fat. At last count, national health statistics pegged two out of three Americans (65 percent of us) as overweight or obese – but even more of us (up to 90% by some measures) fall into a category of people who are Tired, Stressed, and Depressed. The interesting thing for me (as a nutritional biochemist) is that being overweight and being stressed/depressed share some of the same biochemical – or hormonal patterns.

The reason for failure at your previous weight loss attempts really comes down to one primary cause—stress. Stressed-out people eat more (and eat more junk). Stressed-out people have more belly fat (and more diabetes as a result). Stressed-out people exercise less—mostly because they are “time-stressed” and feel they have no time for exercise. Stressed-out people are constantly tired during the day—and yet they can’t relax enough to get a good night of sleep. Stressed-out people also have more heart attacks, more depression, more colds, and less sex. I cannot think of a more dismal picture—and stress is at the root of it.

How is it that something as simple as stress can cause so many problems—from depression to heart disease to weight gain? The reason is because a chronic stress response, such as the one we mount every day when faced with deadlines, traffic, money concerns, family conflicts, irritating coworkers, and other worries, causes an immediate and profound change in a variety of hormones and enzymes and neurotransmitters and other naturally occurring chemicals in our bodies.

For many years, we used to focus primarily on one stress hormone, cortisol, because it is thought of as the “primary” stress hormone. Now, however, we know that although cortisol is still important to consider, it is clearly only one part of the hormonal and metabolic response to stress and weight gain that involves a complex interplay between cortisol with another hormone (testosterone) and with a fat-storing enzyme (HSD) and with neurotransmitters including dopamine and norepinephrine.

That interplay goes something like this:

1.Stress increases cortisol exposure, which in most people leads to increased appetite and abdominal weight gain.

2.Increased cortisol reduces testosterone levels in men and women, leading to a loss of sex drive and muscle mass and an increase in fatigue and body fat.

3.Some people with high stress do not have high levels of cortisol in their blood, but they can still gain weight because of high cortisol levels within their fat cells. Fat cells contain an enzyme, called HSD (or hydroxysteroid dehydrogenase), that increases cortisol levels within the cell as a way to encourage more fat storage (even when cortisol levels in the blood remain normal).

Like many complex problems, the solution is actually not all that complicated—and it looks like this:

1.The “eat less and exercise more” approach to weight loss has failed.

2.Stress makes you fat.

3.Maintain hormonal balance between cortisol (both outside and inside cells) and testosterone.

How can I make such a bold claim—that the solution to the weight-loss puzzle is as simple as three little sound bites? Because for the past six years, hundreds of people in my nutrition clinic and hundreds of thousands of people who have read my books, or read interviews with me in magazines and newspapers, and seen or heard my appearances on television and radio have realized dramatic benefits with my approach to weight-loss. My program has been presented at some of the most prestigious scientific research conferences in the world, including the American College of Nutrition, the International Society for Sports Nutrition, Experimental Biology, the American College of Sports Medicine, and the Obesity Society.

Our weight-loss breakthrough came when we realized that we had been concentrating our efforts too narrowly on controlling cortisol levels in the blood (outside of fat cells) and ignoring the fact that cortisol levels inside of fat cells might still be too high. By naturally controlling the activity of the fat-storing HSD enzyme within fat cells, we could also control cortisol levels within fat cells and thus remove a potent fat-storage signal. When we combined this inside/outside approach to cortisol control with a natural rebalancing of testosterone levels, magic happened in terms of weight loss, but also in terms of how people felt – with better mood, higher energy levels, and sharper mental focus. As a scientist, I think it’s interesting that this so-called “magic” was nothing of the sort, but rather was a very precise approach to balancing normal biochemistry and metabolism. Our approach appeared magical to our participants because they felt great, the plan was easy to follow, and it worked like nothing they had ever tried before. As the scientist and science-fiction writer Arthur C. Clarke so famously stated, “Any sufficiently advanced technology is indistinguishable from magic”—a statement that drives me to constantly advance our biochemical approach to weight loss and feeling better so I can keep the “magic” happening for people.

Don’t get me wrong here: Proper diet and regular exercise are still important pieces of the weight-loss and feel-good puzzle, but they are not the only considerations. We also need to consider the brain (in terms of sleep, stress, mood) and hormone levels (in terms of cortisol and testosterone and compounds that aren’t technically hormones) if we want the most complete approach to truly effective weight loss. How many people try to “eat right” and “exercise more”—and yet still gain weight? Millions! The missing pieces of the puzzle for most people are stress control and biochemical balance—and adding those pieces has made all the difference in the world for participants in our programs over the years. After six years of tracking results, we have a 91 percent completion rate, when typical weight-loss programs are lucky to achieve 50 percent. Our participants don’t just lose weight; they lose significant amounts of body fat, and they feel great doing it because they’re learning to control the hormones that have made them hungry, fat, tired, and depressed.

You have to feel good to stay on a “diet.” If it’s a chore, then you quit—simple as that. Our program reduces depression by 52 percent, reduces fatigue by 48 percent, and boosts overall feelings of well-being by 22 percent (so you feel like a million bucks instead of feeling terrible like you do with every other weight loss plan you’ve tried). Not only do our participants lose body fat, but they also maintain their muscle mass—so they avoid the common drop in metabolic rate (and subsequent weight gain) seen with other weight-loss programs.

I feel very strongly—in fact, I am certain—that once you understand the relationship between modern stressors, your biochemical balance, and their effects on your long-term health, you will be motivated to do something about getting your metabolism back into balance.

Please visit wisdomofbalance.com for more information about achieving and maintaining biochemical balance. I’m Dr. Shawn Talbott – and thanks for listening to the Wisdom of Balance podcast – see you next time.

==================================

Shawn M. Talbott, Ph.D.

Nutritional Biochemist and Author

smtalbott@mac.com

www.shawntalbott.com


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-Killer at Large - an award-winning documentary exploring the causes and solutions underlying the American obesity epidemic (http://www.KilleratLarge.com)

-The Health Professionals Guide to Dietary Supplements (Lippincott, Williams & Wilkens) -http://www.supplementwatch.com/

-Cortisol Control and the Beauty Connection - The All-Natural Inside-Out Approach to Reversing Wrinkles, Preventing Acne, And Improving Skin Tone (Hunter House) -http://www.cortisolcontrol.com/

-Natural Solutions for Pain-Free Living (Chronicle Publishers - Currant Books)

-The Cortisol Connection - Why Stress Makes You Fat and Ruins Your Health (Hunter House) - http://www.cortisolconnection.com/

-The Cortisol Connection Diet - The Breakthrough Program to Control Stress and Lose Weight (Hunter House) - http://www.cortisolconnectiondiet.com/

-A Guide to Understanding Dietary Supplements - an Outstanding Academic Text of 2004 (Haworth Press) - http://www.supplementwatch.com/

Sunday, October 25, 2009

Astragalus

Overview

Astragalus is an herb from traditional Chinese medicine (TCM) which is traditionally used for its immune enhancing properties, but is also recommended in TCM for "deficiency of chi" (life force) – which might include symptoms such as lack of energy and fatigue. Similar to Echinacea, astragalus exhibits immune-enhancing effects from the polysaccharides contained in the root. Modern medical practitioners have recently become involved in researching astragalus in reducing the side effects of chemotherapy, upper respiratory infections, promoting cardiovascular health, hepatoprotection, and male infertility.


Comments

Astragalus has been used as an herbal “tonic” for centuries in Traditional Chinese Medicine (TCM) and in Native American folk medicine. As a tonic, astragalus is used primarily as a “prevention” herb throughout the cold and flu season – a different usage than the more popular Echinacea, which is best used for early stage treatment as soon as you feel a cold or flu coming on. Most of what we know about astragalus, however, comes from test tube and animal experiments, which show that astragalus can help fight bacteria and viruses by enhancing various aspects of the body's normal immune response (enhanced function of specific immune system cells such as T cells, lymphocytes and neutrophils). In TCM, astragalus is often combined with other “tonic” herbs such as Ginseng, Cordyceps or Ashwagandha, to keep the immune system “humming” during periods of high stress.


The scientific evidence for the ability of astragalus to enhance the immune system and improve cardiovascular disease and cancer comes from human, animal, and in vitro studies. Some of these studies show significant beneficial results for astragalus. However, insufficient and unreliable data exists in the uses for this herb. Unless a patient has an autoimmune disease or is taking immune suppressant medications, this herb is an option for treatment and/or symptom relief in various conditions.


Scientific Support

The astragalus root is the part that contains the important saponin and polysaccharide constituents. These saponins have diuretic effects as well as anti-inflammatory and antihypertensive activity. Due to the various elements contained in the plant, (amino acids, coumarins, flavanoids, isoflavanoids, polysaccharides, and trace minerals), it is unclear which agents provide which activities.


Several chemical constituents of astragalus have been identified as potential active compounds, including saponins, flavonoids, polysaccharides and glycosides. Astragalus is often combined with other adaptogenic herbs, such as ginseng, and promoted as a guard against various internal and external stressors. Combination of astragalus with echinacea is common for protection against common infections of the mucous membranes (cold and flu).


Most of the scientific data on astragalus comes from Chinese clinical evidence, where astragalus appears to stimulate the immune system in patients with infections. At least one clinical trial in the U.S. has shown astragalus to boost T-cell levels close to normal in some cancer patients, suggesting the possibility of a synergistic effect of astragalus with chemotherapy. In animal studies, astragalus extracts have been shown effective in preventing infection of mice by influenza virus, possibly by increasing the phagocytotic activity of the white blood cells of the immune system.


In several Chinese studies (Duan et al. 2002, Zou et al. 2003) cancer patients have responded favorably to astragalus preparations (higher remission rate), probably owing to an inhibition of chemotherapy induced immune suppression (lesser decrease of white blood cell count and higher IgG and IgM levels). Numerous animal studies have indicated astragalus also possesses broad antioxidant and hepatoprotective effects, likely due to the presence of a variety of saponin and flavonoid compounds. As a general supporter of immune system function, astragalus has been studied in rodent models and in humans with a generally beneficial, if modest, effect on maintaining immune system function during chemotherapy and radiotherapy (Cha et al. 1994, Niu et al. 2001, Wu et al. 2001).


Safety/Dosage

When used as recommended, astragalus has no known side effects, but gastrointestinal distress and diarrhea are possible at high intakes. Astragalus is available as a single-ingredient supplement, but it may be even more effective in lower doses (100-200mg/day) when combined with other immune-stimulating herbs and nutrients. Approximately 500mg per day is recommended for stimulation of the immune system and to provide resistance to the effects of stress. Divided doses of 250mg per day of a standardized (for saponins and flavonoids) root extract are preferred. Use with caution in autoimmune disease due to the immunostimulating properties of astragalus. Consider discontinuing astragalus prior to surgery as astragalus may increase the risk of bleeding.


References

1.Cha RJ, Zeng DW, Chang QS. Non-surgical treatment of small cell lung cancer with chemo-radio-immunotherapy and traditional Chinese medicine. Zhonghua Nei Ke Za Zhi 1994; 462-6.

2.Chu DT, Lepe-Zuniga J, Wong WL, LaPushin R, Mavligit GM. Fractionated extract of Astragalus membranaceus, a Chinese medicinal herb, potentiates LAK cell cytotoxicity generated by a low dose of recombinant interleukin-2. J Clin Lab Immunol. 1988 Aug;26(4):183-7.

3.Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol. 1988 Mar;25(3):125-9.

4.Duan P, Wang ZM. Clinical study on effect of astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor. Zhongguo Zhong Xi Yi Jie He Za Zhi 2002; 22: 515-7.

5.Li SQ, Yuan RX, Gao H. Clinical observation on the treatment of ischemic heart disease with astragalus membranaceus. Zhongguo Zhong Xi Yi Jie He Za Zhi 1995; 15: 77-80.

6.Liu ZG, Xiong ZM, Yu XY. Effect of astragalus injection on immune function in patients with congestive heart failure. Zhongguo Zhong Xi Yi Jie He Za Zhi 2003; 23: 351-3.

7.Luo HM, Dai RH, Li Y. Nuclear cardiology study on effective ingredients of Astragalus membranaceus in treating heart failure Zhongguo Zhong Xi Yi Jie He Za Zhi 1995; 15: 707-9.

8.Niu HR, Lai ZH, Yuan L. Observation on effect of supplementary treatments by astragalus injection in treating senile pulmonary tuberculosis patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001; 21: 346-50.

9.Rittenhouse JR, Lui PD, Lau BH. Chinese medicinal herbs reverse macrophage suppression induced by urological tumors. J Urol. 1991 Aug;146(2):486-90.

10.Sinclair S. Chinese herbs: a clinical review of Astragalus, Ligusticum, and Schizandrae. Altern Med Rev. 1998 Oct;3(5):338-44.

11.Sun Y, Hersh EM, Talpaz M, Lee SL, Wong W, Loo TL, Mavligit GM. Immune restoration and/or augmentation of local graft versus host reaction by traditional Chinese medicinal herbs. Cancer. 1983 Jul 1;52(1):70-3.

12.Zhang JG, Gao DS, Wei GH. Clinical study on effect of Astragalus injection on left ventricular remodeling and left ventricular function in patients with acute myocardial infarction. Zhongguo Zhong Xi Yi Jie He Za Zhi 2002; 22: 346-8.

13.Zhang ZL, Wen QZ, Liu CX. Hepatoprotective effects of astragalus root. Journal of Ethnopharmacology 1990; 30: 146-49.

14.Zhao KS, Mancini C, Doria G. Enhancement of the immune response in mice by Astragalus membranaceus extracts. Immunopharmacology. 1990 Nov-Dec;20(3):225-33.

15.Zhou ZL, Yu P, Lin D. Study on effect of astragalus injection in treating congestive heart failure. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001; 21: 747-9.


EDITOR'S NOTE: This monograph can be found in The Health Professional's Guide to Dietary Supplements (Lippincott, Williams & Wilkins) by Shawn M. Talbott, PhD and Kerry Hughes, MS.